Muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PWP1, NIFK, and POLA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle hypertrophy activity versus PWP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PWP1 →	+0.820	+1.180	.002	.006	2	5
OVARY	NIFK →	+0.638	+0.823	.004	<.001	3	4
BLOOD_Leukemia	POLA2 →	+0.459	+0.161	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NDUFS1 →	+0.964	+1.385	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CYREN →	+0.815	+1.280	<.001	.003	3	4
PANCREAS	METAP2 →	+0.732	+1.793	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014896 vs PWP1 — UPPER_AERODIGESTIVE_TRACT

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