Striated muscle adaptation

Across TCGA patient cohorts, RNA activity of the Striated muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA4_S647, PMM2, and HDAC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle adaptation activity versus HSPA4_S647 in BRCA (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPA4_S647 →	-0.395	-0.021	.008	.007	3	5
BRCA	PMM2 →	-0.324	-0.025	.002	.003	3	5
LSCC	HDAC4 →	+0.191	+0.060	.007	<.001	3	5
HNSC	HIBADH →	+0.316	+0.072	<.001	<.001	3	5
CCRCC	SYNPO_S685 →	+0.272	+0.027	.004	.008	3	5
LSCC	TUBA4A →	+0.335	+0.042	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014888 vs HSPA4_S647 — BRCA

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