Response to muscle inactivity

Across TCGA patient cohorts, RNA activity of the Response to muscle inactivity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM86C2P, EFHC1, and NMRAL2P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle inactivity activity versus FAM86C2P in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAM86C2P →	+0.320	+0.236	<.001	.001	3	4
GBM	EFHC1 →	+0.533	+0.341	<.001	<.001	3	4
BRCA	NMRAL2P →	+0.297	+0.487	<.001	<.001	3	3
GBM	RFX7 →	+0.377	+0.195	<.001	<.001	3	3
CCRCC	KNOP1P2 →	+0.240	+0.368	.008	.002	3	3
CCRCC	ASNS →	+0.325	+0.299	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014870 vs FAM86C2P — GBM

Explore this scatter interactively →