Skeletal myofibril assembly

Across TCGA patient cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, MYH11_S8, and RSU1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal myofibril assembly activity versus SYNPO2 in HNSC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO2 →	+1.052	+0.247	<.001	<.001	3	7
CCRCC	MYH11_S8 →	+1.357	+0.105	<.001	<.001	3	7
UCEC	RSU1 →	+0.453	+0.095	<.001	<.001	3	7
HNSC	SERBP1 →	-0.198	-0.173	.001	.002	3	7
HNSC	TPM1_S174 →	+0.888	+0.184	<.001	<.001	3	7
HNSC	MECP2 →	+0.480	+0.217	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014866 vs SYNPO2 — HNSC

Explore this scatter interactively →