Skeletal myofibril assembly

Across TCGA patient cohorts, RNA activity of the Skeletal myofibril assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCER1A, TMEM204, and SCN2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal myofibril assembly activity versus FCER1A in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FCER1A →	+0.631	+0.924	.002	.006	3	4
CCRCC	TMEM204 →	+1.012	+0.887	.003	.003	3	4
BRCA	SCN2B →	+0.300	+0.495	.001	<.001	3	4
HNSC	CORO6 →	+1.274	+2.680	.003	.002	3	4
CCRCC	LRCH2 →	+0.719	+1.009	<.001	<.001	3	4
CCRCC	PPFIA2 →	+0.589	+0.922	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014866 vs FCER1A — LSCC

Explore this scatter interactively →