Striated muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Striated muscle cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, SORBS3, and CYBRD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell proliferation activity versus SGCD in OV (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SGCD →	+0.560	+0.027	.004	.002	3	7
PDAC	SORBS3 →	+0.357	+0.045	<.001	<.001	3	7
CCRCC	CYBRD1 →	+0.370	+0.032	<.001	<.001	3	7
COAD	DPYSL3 →	+0.535	+0.021	.002	<.001	3	7
GBM	PLCD1 →	+0.532	+0.028	.001	.001	3	7
COAD	DDAH2 →	+0.427	+0.022	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014855 vs SGCD — OV

Explore this scatter interactively →