Striated muscle cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Striated muscle cell proliferation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 82 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Striated muscle cell proliferation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and UCS, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRP, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.375	0.524	<.001	50	view →
KIRP	DFS	Tertile	All	0.368	0.682	.005	48	view →
LIHC	DFS	Median	All	0.458	0.620	.001	36	view →
ACC	DFS	Quartile	II,III,IV	0.129	0.649	.001	33	view →
KICH	OS	Tertile	II,III,IV	0.288	0.848	.004	32	view →
ESCA	DFS	Tertile	III,IV	0.503	0.252	.015	30	view →
UCS	DFS	Median	III,IV	0.511	0.148	.003	30	view →
COAD	DFS	Tertile	III,IV	0.336	0.680	.002	19	view →
CHOL	OS	Tertile	II,III,IV	0.355	0.869	.006	18	view →
DLBC	DFS	Quartile	All	0.532	0.929	.016	16	view →
KIRC	DFS	Tertile	All	0.600	0.750	.014	12	view →
THCA	DFS	Median	IV	0.865	0.535	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0014855–LGG (OS)

Open the LGG breakdown →