Striated muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Striated muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR181A2HG, PDCL3P5, and LCTL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell proliferation activity versus MIR181A2HG in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MIR181A2HG →	+0.289	+0.566	.003	<.001	3	4
GBM	PDCL3P5 →	+0.487	+0.745	.002	<.001	3	4
COAD	LCTL →	+0.088	+0.442	.002	.005	3	4
LUAD	EMP1 →	+0.660	+0.786	<.001	<.001	3	4
LUAD	RGS3 →	+0.342	+0.647	.002	<.001	3	4
OV	AKT3 →	+0.753	+0.751	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014855 vs MIR181A2HG — CCRCC

Explore this scatter interactively →