Striated muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Striated muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRF, HOXA3, and SLC35D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRF grouped by Striated muscle cell proliferation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTPRF →	+1.337	+1.009	.008	.006	2	4
LUNG_NSCLC_LUSC	HOXA3 →	-2.204	-0.460	.007	.002	3	3
LUNG_NSCLC_LUSC	SLC35D1 →	+1.182	+0.506	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	GON4L →	+1.044	+0.381	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	ZNF684 →	+0.602	+0.334	.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	IDE →	+1.347	+0.333	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRF by Striated muscle cell proliferation activity — OVARY

Explore this box plot interactively →