Response to muscle activity

Across TCGA cell cohorts, RNA activity of the Response to muscle activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPG, GNA14, and CYP27A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPG grouped by Response to muscle activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CAPG →	-2.004	-0.819	.004	.005	3	5
LARGE_INTESTINE	GNA14 →	+0.662	+0.433	.005	.001	3	5
LUNG_NSCLC_LUAD	CYP27A1 →	-1.061	-0.793	.001	<.001	3	5
BLOOD_Myeloma	HMOX1 →	-3.002	-1.615	.005	.008	3	4
LUNG_NSCLC_LUSC	OVOL1 →	+1.856	+1.303	<.001	.004	3	4
LUNG_NSCLC_LUAD	BTG2 →	+1.249	+0.838	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPG by Response to muscle activity activity — OVARY

Explore this box plot interactively →