Regulation of skeletal muscle satellite cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle satellite cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-DPB1, CYTH1, and TRIM21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle satellite cell proliferation activity versus HLA-DPB1 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HLA-DPB1 →	+0.487	+0.089	.009	.001	2	6
GBM	CYTH1 →	+0.271	+0.054	.008	.003	3	5
HNSC	TRIM21 →	+0.389	+0.065	<.001	<.001	3	4
COAD	IDO1 →	+1.314	+0.068	.002	.003	3	4
LSCC	FCHSD2 →	+0.224	+0.049	.004	.001	2	5
LSCC	CCDC86_S113 →	-0.457	-0.047	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014842 vs HLA-DPB1 — UCEC

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