Regulation of skeletal muscle satellite cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle satellite cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPR1A, AGAP5, and CELF2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle satellite cell proliferation activity versus AVPR1A in CCRCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AVPR1A →	-1.275	-0.799	<.001	<.001	3	4
LUAD	AGAP5 →	+0.162	+0.226	.001	.003	3	4
HNSC	CELF2-AS1 →	+0.503	+0.346	.004	.003	3	4
BRCA	JHY →	+0.498	+0.558	.005	.001	3	3
UCEC	TRIM66 →	+0.571	+0.522	<.001	<.001	3	3
UCEC	SATB1 →	+0.850	+0.414	<.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014842 vs AVPR1A — CCRCC

Explore this scatter interactively →