Regulation of skeletal muscle satellite cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle satellite cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, ABHD2, and TGM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HNRNPA1 grouped by Regulation of skeletal muscle satellite cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HNRNPA1 →	-0.497	-0.897	.005	.006	3	5
LIVER	ABHD2 →	+1.818	+1.083	<.001	.002	3	5
BLOOD_Leukemia	TGM2 →	+3.429	+1.284	<.001	.002	3	5
LIVER	HTATIP2 →	+3.299	+1.010	.003	.005	3	5
UPPER_AERODIGESTIVE_TRACT	LIPH →	+2.003	+1.164	.004	.006	3	4
LARGE_INTESTINE	DNPEP →	+0.566	+1.333	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HNRNPA1 by Regulation of skeletal muscle satellite cell proliferation activity — BREAST

Explore this box plot interactively →