Regulation of skeletal muscle satellite cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle satellite cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBFOX2, RHOF, and MAN2C1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle satellite cell proliferation activity versus RBFOX2 in BREAST (Pearson r = -0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBFOX2 →	-1.686	-1.632	.001	<.001	3	2
BREAST	RHOF →	+1.990	+1.609	.009	.007	3	2
BREAST	MAN2C1 →	-1.569	-1.632	.006	<.001	3	2
BREAST	RASSF9 →	-0.376	-1.632	.001	<.001	3	2
OVARY	HMCN1 →	-1.679	-2.128	<.001	<.001	3	2
OVARY	SELENBP1 →	-4.126	-2.128	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014842 vs RBFOX2 — BREAST

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