Skeletal muscle satellite cell proliferation

pathway activity — cross-omics
GO:0014841Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67_S357, MCM4_T110, and RIF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACMKI67_S357 →+0.614+0.054<.001<.00138
LUADMCM4_T110 →+1.053+0.062.003.00137
BRCARIF1 →+0.291+0.033<.001<.00136
BRCARRM2 →+0.447+0.031<.001.00136
BRCARRP36_S73 →+0.520+0.036.003.00436
BRCASMC2 →+0.560+0.045<.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration