Gastro-intestinal system smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Gastro-intestinal system smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT172, SLC6A9, and CASP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT172 grouped by Gastro-intestinal system smooth muscle contraction-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFT172 →	-0.921	-0.715	.007	.009	3	4
KIDNEY	SLC6A9 →	+1.383	+1.460	.003	<.001	3	3
LIVER	CASP1 →	-3.101	-1.457	.004	.008	3	3
BLOOD_Leukemia	ARHGAP17 →	-1.284	-0.313	<.001	.002	3	3
SKIN	APCDD1 →	-1.474	-0.975	.004	.002	3	3
BREAST	COG7 →	-0.557	-0.823	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT172 by Gastro-intestinal system smooth muscle contraction activity — SKIN

Explore this box plot interactively →