Intestine smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Intestine smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPA3, ADH1B, and HSPB6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestine smooth muscle contraction activity versus CPA3 in COAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CPA3 →	+1.013	+0.085	<.001	<.001	3	6
PDAC	ADH1B →	+0.514	+0.048	.001	<.001	3	6
COAD	HSPB6 →	+1.284	+0.088	<.001	<.001	3	6
BRCA	RRM2 →	-0.487	-0.044	<.001	<.001	3	5
COAD	SORBS1 →	+0.617	+0.065	<.001	<.001	3	5
HNSC	SYNPO2 →	+0.703	+0.051	.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014827 vs CPA3 — COAD

Explore this scatter interactively →