Response to activity

Across TCGA patient cohorts, RNA activity of the Response to activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPN1, CALD1_S73, and FCN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to activity activity versus CPN1 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CPN1 →	+0.647	+0.053	<.001	<.001	3	7
GBM	CALD1_S73 →	+0.511	+0.042	.009	.004	3	6
GBM	FCN2 →	+0.618	+0.041	.002	<.001	3	6
CCRCC	GUCY1B1 →	+0.370	+0.043	<.001	<.001	3	6
LUAD	FLT1 →	+0.535	+0.045	<.001	<.001	3	6
GBM	APOA1 →	+0.473	+0.028	.004	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014823 vs CPN1 — GBM

Explore this scatter interactively →