Response to activity

Across TCGA pan-cancer cohorts, RNA activity of the Response to activity pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 72 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Response to activity pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, KIRC, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.218	0.754	<.001	59	view →
KIRC	DFS	Quartile	All	0.875	0.733	.001	53	view →
KICH	OS	Tertile	All	0.707	1.000	.001	50	view →
HNSC	DFS	Median	III,IV	0.721	0.595	.004	41	view →
MESO	OS	Tertile	All	0.239	0.758	<.001	40	view →
ACC	OS	Median	II,III,IV	0.402	0.711	.005	32	view →
UCEC	DFS	Tertile	All	0.774	0.879	.001	30	view →
PAAD	DFS	Tertile	All	0.153	0.362	.008	26	view →
STAD	DFS	Median	All	0.480	0.604	.009	24	view →
BLCA	OS	Quartile	All	0.496	0.688	.005	19	view →
SARC	DFS	Quartile	All	0.143	0.454	.003	15	view →
UCS	OS	Tertile	IV	0.883	0.369	.033	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0014823–KIRP (OS)

Open the KIRP breakdown →