Response to activity

Across TCGA patient cohorts, RNA activity of the Response to activity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHFPL6, PCDH12, and TNS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to activity activity versus LHFPL6 in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LHFPL6 →	+0.851	+0.235	<.001	<.001	3	7
CCRCC	PCDH12 →	+0.785	+0.197	<.001	<.001	3	6
OV	TNS2 →	+1.433	+0.437	<.001	<.001	3	6
CCRCC	HSPA12B →	+0.769	+0.145	<.001	<.001	3	6
CCRCC	PTH1R →	+1.116	+0.123	<.001	.004	3	6
CCRCC	BCL6B →	+0.909	+0.164	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014823 vs LHFPL6 — OV

Explore this scatter interactively →