Response to activity

Across TCGA cell cohorts, RNA activity of the Response to activity pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCKDK, EPCAM, and ST14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCKDK grouped by Response to activity-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BCKDK →	-1.194	-0.401	.001	<.001	3	5
URINARY_TRACT	EPCAM →	+7.200	+0.405	.002	<.001	3	5
URINARY_TRACT	ST14 →	+5.620	+0.418	.004	.001	2	6
URINARY_TRACT	AP1M1 →	-1.813	-0.387	.001	.003	3	5
OESOPHAGUS	TMPRSS13 →	+2.238	+0.289	<.001	<.001	3	5
OESOPHAGUS	ERP27 →	+3.558	+0.274	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCKDK by Response to activity activity — URINARY_TRACT

Explore this box plot interactively →