Response to activity

Across TCGA cell cohorts, RNA activity of the Response to activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALLD, FSTL1, and SUGP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to activity activity versus PALLD in LUNG_NSCLC_LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PALLD →	+1.327	+0.168	.004	.005	3	5
LUNG_NSCLC_LUAD	FSTL1 →	+3.019	+0.234	<.001	.001	3	5
PANCREAS	SUGP1 →	-0.436	-0.204	.002	.002	3	5
BREAST	ITGB1 →	+1.592	+0.313	.003	<.001	3	5
BONE	PLAC8 →	+3.697	+0.278	<.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	SERPINE1 →	+3.955	+0.247	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014823 vs PALLD — LUNG_NSCLC_LUAD

Explore this scatter interactively →