Tonic smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Tonic smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP4_S116, SCAF4, and SF3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tonic smooth muscle contraction activity versus FNBP4_S116 in GBM (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FNBP4_S116 →	-0.333	-0.070	.002	.002	3	6
GBM	SCAF4 →	-0.305	-0.068	<.001	.003	3	5
GBM	SF3B1 →	-0.227	-0.073	<.001	<.001	3	5
GBM	THRAP3 →	-0.251	-0.073	<.001	<.001	3	5
GBM	UTP6 →	-0.182	-0.057	.002	.004	3	5
LSCC	ZNF318_S2101 →	-0.537	-0.073	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014820 vs FNBP4_S116 — GBM

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