Tonic smooth muscle contraction

Across TCGA pan-cancer cohorts, RNA activity of the Tonic smooth muscle contraction pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Tonic smooth muscle contraction pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and KIRC, show the opposite pattern, with higher activity associated with better survival.

CESC, KIRC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	IV	0.737	0.310	.006	52	view →
KIRC	DFS	Median	All	0.720	0.588	.003	39	view →
LGG	DFS	Median	All	0.797	0.680	<.001	38	view →
KIRP	OS	Tertile	III,IV	0.196	0.664	.001	35	view →
ACC	DFS	Tertile	All	0.615	0.255	.001	31	view →
UCS	DFS	Median	IV	0.885	0.440	.015	30	view →
THCA	DFS	Median	All	0.930	0.698	.007	20	view →
ESCA	OS	Quartile	III,IV	0.777	0.488	.021	18	view →
TGCT	DFS	Median	II,III,IV	0.750	0.996	.046	16	view →
OV	OS	Tertile	All	0.730	0.643	.015	16	view →
THYM	DFS	Tertile	All	0.969	0.694	.016	13	view →
UVM	DFS	Quartile	III,IV	0.274	0.896	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0014820–CESC (DFS)

Open the CESC breakdown →