Tonic smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Tonic smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCBP2, PRSS12, and PLEKHJ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYCBP2 grouped by Tonic smooth muscle contraction-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYCBP2 →	-0.705	-0.708	<.001	.002	3	3
URINARY_TRACT	PRSS12 →	+2.014	+0.427	.003	.004	3	3
SKIN	PLEKHJ1 →	-0.369	-0.710	.008	.003	3	3
SKIN	CACYBP →	-0.605	-0.735	.002	.002	3	3
LUNG_NSCLC_LUSC	PHB2 →	-0.926	-0.412	.002	.003	2	4
LARGE_INTESTINE	LIPG →	-1.547	-0.877	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYCBP2 by Tonic smooth muscle contraction activity — PANCREAS

Explore this box plot interactively →