Tonic smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Tonic smooth muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF20L1, PKN2, and BMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHF20L1 grouped by Tonic smooth muscle contraction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PHF20L1 →	+0.115	+0.965	.006	.005	3	5
BREAST	PKN2 →	+0.165	+1.104	<.001	<.001	3	4
KIDNEY	BMP1 →	-0.182	-0.623	<.001	.004	3	4
KIDNEY	SPHK1 →	+0.360	+0.406	.002	.001	3	4
CNS	HTR6 →	-0.163	-0.862	.004	.006	3	4
CNS	ACOT12 →	-0.183	-1.077	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHF20L1 by Tonic smooth muscle contraction activity — LUNG_SCLC

Explore this box plot interactively →