Muscle cell migration

Across TCGA cell cohorts, RNA activity of the Muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDR1, MSH5, and TRMT13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDR1 grouped by Muscle cell migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDR1 →	-0.156	-0.669	<.001	<.001	3	6
BLOOD_Lymphoma	MSH5 →	+0.337	+0.256	<.001	<.001	3	5
LUNG_SCLC	TRMT13 →	-0.205	-0.193	.003	.002	3	4
LUNG_SCLC	MFSD14A →	-0.461	-0.298	.001	.003	2	5
KIDNEY	CFHR3 →	+0.616	+0.322	<.001	.002	3	4
BLOOD_Leukemia	PSG3 →	-0.215	-0.422	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDR1 by Muscle cell migration activity — SKIN

Explore this box plot interactively →