Muscle cell migration

Across TCGA cell cohorts, RNA activity of the Muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDIT3, TFAP4, and SAPCD2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell migration activity versus DDIT3 in OESOPHAGUS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DDIT3 →	+1.742	+0.162	.006	.001	2	12
BONE	TFAP4 →	-1.288	-0.190	<.001	<.001	3	10
BONE	SAPCD2 →	-1.197	-0.152	.001	<.001	3	9
BREAST	CD59 →	+1.177	+0.123	.004	.001	3	8
SOFT_TISSUE	PLAT →	+3.500	+0.189	<.001	<.001	3	8
BONE	MCM4 →	-1.784	-0.222	.008	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014812 vs DDIT3 — OESOPHAGUS

Explore this scatter interactively →