Muscle cell migration

Across TCGA cell cohorts, RNA activity of the Muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QL3, HMGB3, and ACLY, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1QL3 grouped by Muscle cell migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QL3 →	+0.251	+1.335	<.001	.007	3	3
LUNG_NSCLC_LUAD	HMGB3 →	+0.175	+0.231	<.001	<.001	3	3
BREAST	ACLY →	-0.402	-1.047	.003	.002	3	3
BREAST	KCNS3 →	-0.210	-1.160	<.001	.001	3	3
LUNG_SCLC	POMC →	+0.154	+1.671	<.001	<.001	3	3
LUNG_NSCLC_LUAD	CNP →	+0.136	+0.210	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1QL3 by Muscle cell migration activity — LARGE_INTESTINE

Explore this box plot interactively →