Regulation of somitogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of somitogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PECR, SPATA20, and JOSD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PECR grouped by Regulation of somitogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PECR →	-1.884	-1.400	.001	<.001	2	5
PANCREAS	SPATA20 →	-0.921	-1.149	.007	.007	3	4
BLOOD_Leukemia	JOSD2 →	-1.476	-1.346	<.001	<.001	3	4
BLOOD_Leukemia	MRFAP1 →	-0.560	-1.294	.004	.005	2	4
UPPER_AERODIGESTIVE_TRACT	PPP1R35 →	-1.460	-1.532	.006	.001	3	3
BLOOD_Lymphoma	KRTCAP3 →	-0.880	-1.773	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PECR by Regulation of somitogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →