Positive regulation of muscle adaptation

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCLAF1, CEP57, and CEP57L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle adaptation activity versus BCLAF1 in OV (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BCLAF1 →	+0.472	+0.209	<.001	<.001	3	4
BRCA	CEP57 →	+0.371	+0.524	.002	.007	3	4
GBM	CEP57L1 →	+0.509	+0.711	<.001	.005	3	4
GBM	TUBA5P →	+0.663	+0.593	.002	.003	3	4
HNSC	WASH8P →	+0.826	+0.675	.009	<.001	3	3
LSCC	FAM229B →	+0.393	+0.500	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014744 vs BCLAF1 — OV

Explore this scatter interactively →