Regulation of muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Regulation of muscle hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP10_S365, RSU1, and TLN1_S1164, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle hypertrophy activity versus USP10_S365 in COAD (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	USP10_S365 →	-0.305	-0.034	.007	<.001	3	8
BRCA	RSU1 →	+0.378	+0.030	<.001	<.001	3	6
LSCC	TLN1_S1164 →	+0.482	+0.033	.003	.003	3	6
BRCA	VIM_S22 →	+0.802	+0.040	<.001	<.001	3	6
BRCA	VIM_S72 →	+0.792	+0.043	<.001	<.001	3	6
COAD	CORO2B →	+0.863	+0.046	.002	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014743 vs USP10_S365 — COAD

Explore this scatter interactively →