Regulation of muscle hypertrophy

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of muscle hypertrophy pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 64 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of muscle hypertrophy pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, MESO, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.806	0.637	<.001	97	view →
MESO	OS	Median	III,IV	0.306	0.539	.004	62	view →
THCA	DFS	Tertile	II,III,IV	0.636	0.933	.001	53	view →
ACC	DFS	Quartile	All	0.144	0.612	<.001	49	view →
LIHC	OS	Median	All	0.688	0.829	<.001	46	view →
BRCA	OS	Quartile	III,IV	0.923	0.746	.002	37	view →
CESC	DFS	Quartile	III,IV	0.254	0.733	.014	26	view →
SKCM	DFS	Tertile	All	0.692	0.540	<.001	23	view →
OV	DFS	Quartile	III,IV	0.277	0.389	.008	22	view →
SARC	DFS	Tertile	All	0.683	0.513	.007	18	view →
KICH	DFS	Median	II,III,IV	0.704	0.961	.009	16	view →
CHOL	OS	Quartile	All	0.355	0.925	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0014743–HNSC (DFS)

Open the HNSC breakdown →