Regulation of muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Regulation of muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PVRIG, SDC3, and PDIA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PVRIG grouped by Regulation of muscle hypertrophy-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PVRIG →	+0.457	+0.850	.004	.003	3	4
BLOOD_Myeloma	SDC3 →	-1.245	-1.230	.001	.003	3	4
SOFT_TISSUE	PDIA5 →	-1.913	-1.441	.001	<.001	3	4
SOFT_TISSUE	SEMA4F →	-1.993	-1.345	.005	<.001	3	4
KIDNEY	RAB3IL1 →	+1.145	+1.239	<.001	<.001	3	3
STOMACH	ME1 →	+2.049	+1.126	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PVRIG by Regulation of muscle hypertrophy activity — SKIN

Explore this box plot interactively →