Positive regulation of muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTBN1, RPL4, and MYO9B_S1405, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle hypertrophy activity versus SPTBN1 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPTBN1 →	+0.260	+0.037	.005	.007	3	5
BRCA	RPL4 →	-0.331	-0.032	.001	.006	3	4
BRCA	MYO9B_S1405 →	+0.545	+0.054	<.001	<.001	3	4
BRCA	NOC2L →	-0.240	-0.037	.007	.002	3	4
LSCC	TUBA4A →	+0.398	+0.043	.002	.007	3	4
COAD	ENSA_S109 →	-0.870	-0.042	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014742 vs SPTBN1 — GBM

Explore this scatter interactively →