Positive regulation of muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, MYBL2, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle hypertrophy activity versus E2F1 in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	E2F1 →	-0.689	-0.148	.003	.008	2	6
BRCA	MYBL2 →	-1.002	-0.240	.004	.008	3	4
BRCA	CDC6 →	-0.701	-0.330	.002	<.001	3	4
UCEC	STX12 →	+0.340	+0.181	.004	.005	3	4
UCEC	SH3BGRL →	+0.388	+0.136	.003	.003	3	4
OV	CAMK2D →	+0.642	+0.133	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014742 vs E2F1 — LSCC

Explore this scatter interactively →