Positive regulation of muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MROH1, KIFC2, and MISP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MROH1 grouped by Positive regulation of muscle hypertrophy-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MROH1 →	-0.937	-1.863	.001	<.001	3	5
LUNG_NSCLC_LUSC	KIFC2 →	-1.051	-0.965	.001	.003	3	4
LUNG_NSCLC_LUAD	MISP3 →	-1.079	-0.718	.001	.005	3	4
LUNG_NSCLC_LUAD	SLC16A13 →	-0.892	-0.779	.008	.005	3	4
LUNG_NSCLC_LUAD	C8orf82 →	-0.837	-0.630	<.001	.002	3	4
LARGE_INTESTINE	LRRC41 →	+0.572	+1.119	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MROH1 by Positive regulation of muscle hypertrophy activity — BLOOD_Lymphoma

Explore this box plot interactively →