Regulation of skeletal muscle adaptation

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCNL1, SLK, and SETD1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LCNL1 grouped by Regulation of skeletal muscle adaptation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LCNL1 →	+0.100	+0.935	.008	.001	3	4
BLOOD_Myeloma	SLK →	+0.907	+1.472	.006	<.001	3	4
LARGE_INTESTINE	SETD1B →	+0.938	+1.871	.006	<.001	3	4
CNS	TNRC6B →	+0.607	+1.019	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	GGT1 →	+2.933	+1.844	<.001	.001	3	3
PANCREAS	WWC1 →	-1.630	-1.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LCNL1 by Regulation of skeletal muscle adaptation activity — BREAST

Explore this box plot interactively →