Regulation of skeletal muscle adaptation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of skeletal muscle adaptation pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Regulation of skeletal muscle adaptation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and KIRC, show the opposite pattern, with higher activity associated with better survival.

SKCM, COAD, and THYM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.144	0.264	<.001	62	view →
COAD	OS	Median	IV	0.591	0.290	.002	40	view →
THYM	DFS	Tertile	All	0.501	1.000	.001	29	view →
BLCA	DFS	Tertile	All	0.162	0.412	.004	27	view →
MESO	OS	Tertile	All	0.374	0.623	.005	22	view →
PAAD	OS	Median	II,III,IV	0.324	0.560	.020	20	view →
UCEC	DFS	Median	III,IV	0.724	0.845	.013	14	view →
KICH	DFS	Median	All	0.769	1.000	.020	12	view →
KIRC	DFS	Quartile	II,III,IV	0.810	0.625	.007	12	view →
ACC	OS	Tertile	III,IV	0.779	0.314	.014	11	view →
CHOL	DFS	Tertile	All	0.247	0.677	.022	9	view →
READ	OS	Tertile	IV	0.405	0.878	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0014733–SKCM (DFS)

Open the SKCM breakdown →