Regulation of skeletal muscle adaptation

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle adaptation pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PHA-793887, ARRY-520, and Tanespimycin, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHA-793887 grouped by Regulation of skeletal muscle adaptation-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PHA-793887 →	-1.034	-2.159	.038	.039	3	1
CNS	ARRY-520 →	-1.139	-1.779	.049	.007	3	1
CNS	Tanespimycin →	-0.705	-1.779	.031	.007	2	1
CNS	Pictilisib →	-0.405	-1.717	.012	.008	2	1
CNS	Fulvestrant →	-0.365	-1.717	.003	.008	2	1
CNS	OSU-03012 →	-0.429	-2.129	.009	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHA-793887 by Regulation of skeletal muscle adaptation activity — CNS

Explore this box plot interactively →