Skeletal muscle atrophy

Across TCGA patient cohorts, RNA activity of the Skeletal muscle atrophy pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITSN1_S902, LTBP4, and GBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle atrophy activity versus ITSN1_S902 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITSN1_S902 →	-0.569	-0.078	<.001	.005	3	6
PDAC	LTBP4 →	-0.566	-0.084	<.001	<.001	3	6
BRCA	GBP1 →	+0.530	+0.054	<.001	<.001	3	5
PDAC	HSPA12A →	-0.552	-0.076	<.001	<.001	3	5
LUAD	ICAM1 →	+0.607	+0.056	<.001	.003	3	5
BRCA	SMOC2 →	-0.484	-0.054	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014732 vs ITSN1_S902 — BRCA

Explore this scatter interactively →