Skeletal muscle atrophy

Across TCGA pan-cancer cohorts, RNA activity of the Skeletal muscle atrophy pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Skeletal muscle atrophy pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as DLBC and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, DLBC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.253	0.624	.005	31	view →
DLBC	DFS	Median	All	0.849	0.298	<.001	28	view →
KIRC	DFS	Median	III,IV	0.542	0.730	.005	27	view →
KIRP	OS	Quartile	All	0.515	0.761	.001	26	view →
SKCM	OS	Quartile	All	0.962	0.833	.013	16	view →
HNSC	DFS	Median	III,IV	0.492	0.696	.007	16	view →
BRCA	DFS	Median	III,IV	0.856	0.737	.007	13	view →
CHOL	OS	Tertile	III,IV	0.161	0.806	.038	12	view →
STAD	OS	Tertile	III,IV	0.205	0.509	.010	9	view →
PAAD	DFS	Median	III,IV	0.370	0.853	.010	9	view →
ACC	DFS	Quartile	III,IV	0.162	0.786	.019	9	view →
GBM	OS	Tertile	All	0.445	0.302	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0014732–UVM (DFS)

Open the UVM breakdown →