Skeletal muscle atrophy

Across TCGA cell cohorts, RNA activity of the Skeletal muscle atrophy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4E3, RAB11FIP4, and PDCD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4E3 grouped by Skeletal muscle atrophy-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF4E3 →	-2.084	-1.339	.001	.001	3	4
CNS	RAB11FIP4 →	-1.632	-0.746	<.001	.003	3	4
OESOPHAGUS	PDCD6 →	+0.741	+0.352	.004	.004	3	4
LUNG_SCLC	IL13RA1 →	+3.315	+1.352	.002	.002	3	3
LUNG_SCLC	NONO →	-0.658	-1.532	.006	.006	3	3
BLOOD_Leukemia	INSR →	-2.678	-1.815	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4E3 by Skeletal muscle atrophy activity — BLOOD_Leukemia

Explore this box plot interactively →