Skeletal muscle satellite cell activation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle satellite cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf48, PIGZ, and IDE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C4orf48 grouped by Skeletal muscle satellite cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C4orf48 →	-3.805	-0.336	.001	.003	2	4
BLOOD_Myeloma	PIGZ →	+0.790	+2.053	.002	.002	3	3
SKIN	IDE →	+0.509	+1.162	.006	.002	3	3
BLOOD_Myeloma	REEP2 →	+3.570	+2.053	<.001	.002	3	2
BLOOD_Myeloma	NUDT7 →	-3.449	-2.053	<.001	.002	3	2
LUNG_NSCLC_LUSC	MYO10 →	-2.469	-0.319	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C4orf48 by Skeletal muscle satellite cell activation activity — STOMACH

Explore this box plot interactively →