Response to amine

Across TCGA patient cohorts, RNA activity of the Response to amine pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THRAP3_S444, PBXIP1_S43, and LMNA_S423, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amine activity versus THRAP3_S444 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	THRAP3_S444 →	+0.746	+0.050	<.001	.002	3	7
PDAC	PBXIP1_S43 →	+0.547	+0.043	<.001	<.001	3	7
BRCA	LMNA_S423 →	+1.144	+0.043	<.001	<.001	3	6
CCRCC	PARP10_S431 →	+0.602	+0.044	.001	.002	3	6
BRCA	PARP4_S1186 →	+0.630	+0.061	<.001	<.001	3	6
OV	SRRM2_S1694 →	-0.833	-0.043	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014075 vs THRAP3_S444 — CCRCC

Explore this scatter interactively →