Response to purine-containing compound

Across TCGA patient cohorts, RNA activity of the Response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACO1, ATIC, and IGKV1D-13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to purine-containing compound activity versus TACO1 in BRCA (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TACO1 →	-0.425	-0.126	<.001	<.001	3	5
BRCA	ATIC →	-0.387	-0.153	<.001	<.001	3	4
OV	IGKV1D-13 →	+1.376	+0.143	.007	.002	3	4
BRCA	MRPS7 →	-0.287	-0.109	.007	.001	3	4
BRCA	TK1 →	-0.787	-0.145	.001	.003	3	4
BRCA	TRAIP →	-0.560	-0.159	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014074 vs TACO1 — BRCA

Explore this scatter interactively →