Regulation of norepinephrine secretion

Across TCGA cell cohorts, RNA activity of the Regulation of norepinephrine secretion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBF4, NDST2, and ASS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EBF4 grouped by Regulation of norepinephrine secretion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EBF4 →	+2.208	+1.282	.008	.002	3	4
LUNG_NSCLC_LUSC	NDST2 →	+0.749	+1.504	<.001	<.001	3	4
STOMACH	ASS1 →	+2.585	+1.028	.003	.004	3	3
STOMACH	SLC7A2 →	+1.790	+1.027	.004	.004	3	3
STOMACH	FRYL →	-0.886	-1.569	.001	<.001	3	3
CNS	HHEX →	+1.552	+0.988	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EBF4 by Regulation of norepinephrine secretion activity — STOMACH

Explore this box plot interactively →