Negative regulation of glutamate secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of glutamate secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LUZP1, NEXN_S218, and FOXO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glutamate secretion activity versus LUZP1 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LUZP1 →	+0.244	+0.610	.003	<.001	3	6
UCEC	NEXN_S218 →	+1.059	+0.731	<.001	<.001	3	6
COAD	FOXO1 →	+0.382	+0.108	.001	.003	3	5
LSCC	SFXN3 →	+0.485	+0.708	<.001	<.001	3	5
HNSC	SPARC →	+0.627	+0.864	<.001	<.001	3	5
HNSC	FHOD1 →	+0.424	+0.846	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014050 vs LUZP1 — LSCC

Explore this scatter interactively →