Negative regulation of glutamate secretion

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of glutamate secretion pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher Negative regulation of glutamate secretion pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LAML and ACC, show the opposite pattern, with higher activity associated with better survival.

LAML, ACC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.513	0.246	<.001	48	view →
ACC	OS	Quartile	All	0.813	0.315	<.001	42	view →
KIRC	DFS	Median	All	0.724	0.849	.003	39	view →
THCA	OS	Median	III,IV	0.987	0.745	.004	37	view →
THYM	OS	Median	All	0.914	1.000	.005	25	view →
HNSC	OS	Quartile	All	0.625	0.829	.002	24	view →
KIRP	DFS	Median	All	0.859	0.951	.001	21	view →
DLBC	DFS	Median	III,IV	0.887	0.317	.007	20	view →
LUSC	OS	Quartile	All	0.670	0.788	.014	19	view →
UCS	DFS	Median	III,IV	0.502	0.155	.011	18	view →
UCEC	OS	Median	All	0.838	0.902	.011	14	view →
READ	DFS	Tertile	II,III,IV	0.920	0.707	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0014050–LAML (DFS)

Open the LAML breakdown →