Glutamate secretion

Across TCGA patient cohorts, RNA activity of the Glutamate secretion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD7, MAP1B_S2209, and RSU1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate secretion activity versus SETD7 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SETD7 →	+0.308	+0.033	.002	.002	2	6
LSCC	MAP1B_S2209 →	+0.980	+0.049	<.001	<.001	3	5
UCEC	RSU1 →	+0.445	+0.058	.003	.001	3	5
GBM	SHOC2 →	+0.227	+0.050	<.001	<.001	3	5
BRCA	SIN3A_S832 →	-0.378	-0.029	<.001	.003	3	5
OV	COPZ2 →	+0.749	+0.040	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014047 vs SETD7 — OV

Explore this scatter interactively →